Vol. 6, Issue 1, Part A (2024)

Background: Acute-on-Chronic Liver Failure (ACLF) is a complex and life-threatening condition characterized by acute decompensation of chronic liver disease, often triggered by infections, alcohol, or other insults. Despite advancements in the understanding of ACLF, the prognosis remains poor, and treatment outcomes vary widely depending on several factors. Evaluating the effectiveness of different treatment modalities is crucial for improving patient management and outcomes.
Objective: This study aims to evaluate treatment outcomes in patients with ACLF, focusing on survival rates, prognostic factors, and the effectiveness of specific therapeutic interventions, including liver transplantation.
Methods: A retrospective cohort study was conducted using data from 500 patients diagnosed with ACLF at tertiary care centers over the past five years. Data were analyzed to assess survival rates, treatment outcomes, and the impact of various interventions, including medical management, liver support therapies, and liver transplantation. Statistical analyses were performed to identify key prognostic factors influencing outcomes.
Results: The overall survival rate at 28 days was 55%, with significant variation depending on the severity of ACLF and the type of treatment received. Liver transplantation offered the highest survival benefit, with a 28-day survival rate of 85%. Medical management alone was associated with a 40% survival rate, while liver support therapies showed intermediate outcomes. Prognostic factors such as the presence of systemic infections, renal failure, and the degree of hepatic encephalopathy significantly influenced survival.
Conclusion: Treatment outcomes in ACLF are highly variable, with liver transplantation providing the best chance of survival. Early identification of prognostic factors and timely intervention are critical in improving outcomes. Further research is needed to optimize treatment strategies and improve survival rates for patients with ACLF.