Vol. 7, Issue 1, Part A (2025)

One of the main causes of maternal and perinatal death globally is hypertensive disorders of pregnancy. A pregnancy condition known as preeclampsia, with or without severe symptoms, is characterized by new-onset hypertension, typically accompanied by proteinuria, and normally develops after 20 weeks of gestation and often close to term. The aim of this research paper is to investigation of insulin resistance and some antioxidant markers in women with Pre-eclampsia (PE). This study included three groups (total n=60), fourteen pregnant women with pre-eclampsia (PE, n=40) and based on gestational age and disease severity, these chosen pre-eclamptic pregnant women were split into two groups, first age PE1 (n=20) (18-30 years), the second age PE2 (n=20) (31-41), and third group (n=20) as gestational age (17-40) without PE (CONT) as a control group. The results shown significant differences in the biochemical markers (INS, FBG, HOMA-IR, TAO-C and MDA) between pre-eclamptic women groups (PE1 and PE2) and control. The study demonstrates a strong association between insulin resistance and oxidative stress in pre-eclamptic pregnancies. These disturbances are more pronounced in older patients, suggesting that maternal age may influence the severity of PE. Early identification of metabolic and oxidative markers could aid in risk stratification and management of pre-eclampsia.